Acne vulgaris (AV) is a chronic inflammatory of pilosebaceous units. It is characterized by seborrhoea, comedones, papules, pustules, nodules, pseudocyst, and possible scarring. Comedones are the pathognomonic lesions of AV. Predilection of AV is in area with a high density of sebaceous glands, such as the face, upper anterior and posterior trunk. Currently it is known that altered proportion of blood lipoprotein is associated with AV incidences.

The increase of cholesterol levels leads to the elevation of androgen levels which increases sebum and keratinocyte hyperproliferation on AV patients. Sebaceous gland has the ability to synthesize enzymatically androgen de novo from cholesterol or dehidroepiandrosterone (DHE). The latest data indicated a strong association between increased sebaceous lipid synthesis and inflammation, that was considered important in the initiation of AV lesion.